To help prepare for public health emergencies, medical countermeasures MCMs may be stockpiled by governments and even by some private sector partners. For example, the U. Some state and local governments and private sector entities also stockpile MCMs to have ready access to them if an emergency were to occur. A medical product is typically labeled by the manufacturer with an expiration date. This reflects the time period during which the product is expected to remain stable, or retain its identity, strength, quality, and purity, when it is properly stored according to its labeled storage conditions. Expiration dating can present challenges to MCM stockpilers because MCMs that have reached their labeled expiration date in most cases cannot be used.
Profile as promise: A framework for conceptualizing veracity in online dating self-presentations
This guide will assist schools and school districts in developing comprehensive policies addressing healthy relationships and abuse intervention and response. The guide also offers ideas and examples for developing procedures that are responsive to the needs of all student survivors. NRCDV gathered select resources that can offer helpful guidance for domestic violence programs in preparing for and responding to the coronavirus pandemic.
It is widely recognized that many genes and lineages do not adhere to a molecular clock, yet molecular clocks are commonly used to date divergences in comparative genomic studies. We test the application of a molecular clock across genes and lineages in a phylogenetic framework utilizing 12 genes linked in a 1-Mb region on chromosome 13 of soybean Glycine max ; homoeologous copies of these genes formed by polyploidy in Glycine; and orthologous copies in G.
We compare divergence dates estimated by two methods each in three frameworks: a global molecular clock with a single rate across genes and lineages using full and approximate likelihood methods based on synonymous substitutions, a gene-specific clock assuming rate constancy over lineages but allowing a different rate for each gene, and a relaxed molecular clock where rates may vary across genes and lineages estimated under penalized likelihood and Bayesian inference.
We use the cumulative variance across genes as a means of quantifying precision. Our results suggest that divergence dating methods produce results that are correlated, but that older nodes are more variable and more difficult to estimate with precision and accuracy. We also find that models incorporating less rate heterogeneity estimate older dates of divergence than more complex models, as node age increases.
A mixed model nested analysis of variance testing the effects of framework, method, and gene found that framework had a significant effect on the divergence date estimates but that most variation among dates is due to variation among genes, suggesting a need to further characterize and understand the evolutionary phenomena underlying rate variation within genomes, among genes, and across lineages.
Abstract It is widely recognized that many genes and lineages do not adhere to a molecular clock, yet molecular clocks are commonly used to date divergences in comparative genomic studies. Gov’t, Non-P.
Early Medieval Irish literature 7th—10th centuries is vast in extent and rich in genres, but owing to its mostly anonymous transmission, for most texts the precise time and circumstances of composition are unknown. Unless where texts contain historical references, the only clues for a rough chronological positioning of the texts are to be found in their linguistic peculiarities. Phonology, morphology, syntax and the lexicon of the Irish language changed considerably from Early Old Irish 7th c.
However, only the relative sequence of changes is well understood; for most sound changes very few narrow dates have been proposed so far. It is the aim of Chronologicon Hibernicum to find a common solution for both problems: through the linguistic profiling of externally dated texts esp. Groundbreakingly, this will be done by using statistical methods for the seriation of the data, and for estimating dates using Bayesian inference.
the Creative Commons Attribution License. Developing a multi-methods dating framework for the Eastern. Mediterranean region over the Late Quaternary.
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As we saw in Chapter 5, the empirical evidence regarding the effectiveness of primary interventions to change attitudes or ADV behaviours is mixed. However, understanding whether the intervention impacts on the outcome variable of choice is only one aspect to conducting successful evaluations. If interventions for ADV are going to be implemented, then we have an ethical obligation to ensure that they are designed to reflect evidence regarding what works.
In Chapter 6 we introduced the Intervention Mapping Bartholomew et al. By combining intervention and evaluation design we can guarantee that the outcome and impact measures used actually reflect the intervention framework developed. The aim is to provide a comprehensive evaluation framework detailing the main issues that practitioners and evaluation scientists need to consider when evaluating ADV interventions specifically.
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Behavioral frameworks for understanding partner violence may show promise in guiding the development of innovative dating violence prevention programs.
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